association between interleukin-8 -251t/a polymorphism and endometriosis in iranian women
نویسندگان
چکیده
bachground: endometriosis is a disease of female genital system, which is defined by the presence of ectopic endometrial tissue outside the uterine cavity. il-8 is an autocrine growth factor in the endometrium that contributes to the pathogenesis of endometriosis. the aim of this study was to investigate the association between -251t/a polymorphism in the il-8 gene and endometriosis risk in iranian population. materials and methods: this case-control study was performed on 100 endometriosis patients and 100 healthy individuals. the il-8 -251t/a genotypes were determined using pcr-rflp method. the association between genotypes of the -251t/a polymorphism and the endometriosis risk was examined by use of odds ratios (or) and 95% of confidence intervals (cis). results: no statistically significant associations were observed between il-8 -251 variants and the risk of endometriosis development (&chi2;: 1.02, p: 0.63). in addition, subgroup analysis according to severity of disease, were unable to identify any association between il-8 -251t/a polymorphism and endometriosis (p>0.05), and there was no significant association between il-8 -251t/a and the severity of endometriosis. conclusions: this is the first study regard to association of -251t/a polymorphism with endometriosis risk. our results indicate that the presence of the -251t/a polymorphism in il-8 gene is not associated with the risk of endometriosis.
منابع مشابه
Association between Interleukin-8 -251T/A Polymorphism and Endometriosis in Iranian Women
Bachground: Endometriosis is a disease of female genital system, which is defined by the presence of ectopic endometrial tissue outside the uterine cavity. IL-8 is an autocrine growth factor in the endometrium that contributes to the pathogenesis of endometriosis. The aim of this study was to investigate the association between -251T/A polymorphism in the IL-8 gene and endometriosis risk in Ira...
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عنوان ژورنال:
research in molecular medicineجلد ۳، شماره ۲، صفحات ۴۵-۴۹
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